Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens

<p><strong>Background:</strong> In humans and other animals, the chronic hypoxic response is mediated by hypoxia inducible transcription factors (HIFs) which regulate the expression of genes that counteract the effects of limiting oxygen. Prolyl hydroxylases (PHDs) act as hypoxia s...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Lippl, K, Boleininger, A, McDonough, M, Abboud, M, Tarhonskaya, H, Chowdhury, R, Loenarz, C, Schofield, C
التنسيق:	Journal article
منشور في:	Dove Medical Press 2018

مواد مشابهة

The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens
حسب: Loenarz, C, وآخرون
منشور في: (2010)

The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens.
حسب: Loenarz, C, وآخرون
منشور في: (2011)

The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens
حسب: Loenarz, C, وآخرون
منشور في: (2011)

Exploring the substrate selectivity of oxygen sensing prolyl hydroxylases
حسب: Lippl, K, وآخرون
منشور في: (2015)

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii
حسب: Liu, T, وآخرون
منشور في: (2020)

Evolution of PHDs as oxygen sensors: mechanistic and structural studies of the PHD of Trichoplax adhaerens, the simplest animal, and mechanistic studies of a PHD-like enzyme of the protist Monosiga brevicollis
حسب: Boleininger, A
منشور في: (2012)

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
حسب: Chowdhury, R, وآخرون
منشور في: (2009)

Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain
حسب: Abboud, M, وآخرون
منشور في: (2018)

Differentiation of Crystal Cells, Gravity-Sensing Cells in the Placozoan <i>Trichoplax adhaerens</i>
حسب: Tatiana D. Mayorova
منشور في: (2021-11-01)

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
حسب: Holt-Martyn, J, وآخرون
منشور في: (2019)

Mass spectrometric studies on an oxygen sensing prolyl hydroxylase
حسب: Mecinovic, J, وآخرون
منشور في: (2007)

Substrate selectivity of prolyl hydroxylases
حسب: McDonough, M
منشور في: (2018)

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
حسب: Mecinović, J, وآخرون
منشور في: (2009)

Inhibition of a viral prolyl hydroxylase
حسب: Langley, G, وآخرون
منشور في: (2019)

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases
حسب: Horita, S, وآخرون
منشور في: (2015)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
حسب: Holt-Martyn, JP, وآخرون
منشور في: (2019)

Structural basis of prolyl hydroxylase domain inhibition by Molidustat
حسب: Figg, WD, وآخرون
منشور في: (2021)

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
حسب: McDonough, M, وآخرون
منشور في: (2006)

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.
حسب: Flashman, E, وآخرون
منشور في: (2008)

Cells containing aragonite crystals mediate responses to gravity in Trichoplax adhaerens (Placozoa), an animal lacking neurons and synapses.
حسب: Tatiana D Mayorova, وآخرون
منشور في: (2018-01-01)

2-oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
حسب: Abboud, M, وآخرون
منشور في: (2018)

Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding
حسب: Thinnes, C, وآخرون
منشور في: (2018)

Mechanism of molecular oxygen diffusion in a hypoxia-sensing prolyl hydroxylase using multiscale simulation
حسب: Domene, C, وآخرون
منشور في: (2020)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
حسب: Lippl, K
منشور في: (2018)

Bioeffects of Prunus spinosa L. fruit ethanol extract on reproduction and phenotypic plasticity of Trichoplax adhaerens Schulze, 1883 (Placozoa)
حسب: Maria Cristina Albertini, وآخرون
منشور في: (2019-04-01)

Trichoplax adhaerens reveals a network of nuclear receptors sensitive to 9-cis-retinoic acid at the base of metazoan evolution
حسب: Jan Philipp Novotný, وآخرون
منشور في: (2017-09-01)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
حسب: Cockman, M, وآخرون
منشور في: (2019)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
حسب: Yeh, TL, وآخرون
منشور في: (2017)

A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation
حسب: Li, Z, وآخرون
منشور في: (2020)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
حسب: Chan, M, وآخرون
منشور في: (2016)

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
حسب: Figg, WD, وآخرون
منشور في: (2023)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)
حسب: Chowdhury, R, وآخرون
منشور في: (2011)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
حسب: Chowdhury, R, وآخرون
منشور في: (2011)

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
حسب: Tarhonskaya, H, وآخرون
منشور في: (2014)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
حسب: Chowdhury, R, وآخرون
منشور في: (2016)

BIOL 56-ESI-MS studies on prolyl hydroxylase domain 2
حسب: Mecinovic, J, وآخرون
منشور في: (2008)

Structural and mechanistic studies on prolyl hydroxylases
حسب: Chowdhury, R
منشور في: (2008)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
حسب: Astuti, D, وآخرون
منشور في: (2010)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
حسب: Matthew E Cockman, وآخرون
منشور في: (2019-09-01)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
حسب: Chowdhury, R, وآخرون
منشور في: (2013)