Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens

<p><strong>Background:</strong> In humans and other animals, the chronic hypoxic response is mediated by hypoxia inducible transcription factors (HIFs) which regulate the expression of genes that counteract the effects of limiting oxygen. Prolyl hydroxylases (PHDs) act as hypoxia s...

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Manylion Llyfryddiaeth
Prif Awduron:	Lippl, K, Boleininger, A, McDonough, M, Abboud, M, Tarhonskaya, H, Chowdhury, R, Loenarz, C, Schofield, C
Fformat:	Journal article
Cyhoeddwyd:	Dove Medical Press 2018

Eitemau Tebyg

The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens
gan: Loenarz, C, et al.
Cyhoeddwyd: (2010)

The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens.
gan: Loenarz, C, et al.
Cyhoeddwyd: (2011)

The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens
gan: Loenarz, C, et al.
Cyhoeddwyd: (2011)

Exploring the substrate selectivity of oxygen sensing prolyl hydroxylases
gan: Lippl, K, et al.
Cyhoeddwyd: (2015)

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii
gan: Liu, T, et al.
Cyhoeddwyd: (2020)

Evolution of PHDs as oxygen sensors: mechanistic and structural studies of the PHD of Trichoplax adhaerens, the simplest animal, and mechanistic studies of a PHD-like enzyme of the protist Monosiga brevicollis
gan: Boleininger, A
Cyhoeddwyd: (2012)

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
gan: Chowdhury, R, et al.
Cyhoeddwyd: (2009)

Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain
gan: Abboud, M, et al.
Cyhoeddwyd: (2018)

Differentiation of Crystal Cells, Gravity-Sensing Cells in the Placozoan <i>Trichoplax adhaerens</i>
gan: Tatiana D. Mayorova
Cyhoeddwyd: (2021-11-01)

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
gan: Holt-Martyn, J, et al.
Cyhoeddwyd: (2019)

Mass spectrometric studies on an oxygen sensing prolyl hydroxylase
gan: Mecinovic, J, et al.
Cyhoeddwyd: (2007)

Substrate selectivity of prolyl hydroxylases
gan: McDonough, M
Cyhoeddwyd: (2018)

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
gan: Mecinović, J, et al.
Cyhoeddwyd: (2009)

Inhibition of a viral prolyl hydroxylase
gan: Langley, G, et al.
Cyhoeddwyd: (2019)

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases
gan: Horita, S, et al.
Cyhoeddwyd: (2015)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
gan: Holt-Martyn, JP, et al.
Cyhoeddwyd: (2019)

Structural basis of prolyl hydroxylase domain inhibition by Molidustat
gan: Figg, WD, et al.
Cyhoeddwyd: (2021)

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
gan: McDonough, M, et al.
Cyhoeddwyd: (2006)

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.
gan: Flashman, E, et al.
Cyhoeddwyd: (2008)

Cells containing aragonite crystals mediate responses to gravity in Trichoplax adhaerens (Placozoa), an animal lacking neurons and synapses.
gan: Tatiana D Mayorova, et al.
Cyhoeddwyd: (2018-01-01)

2-oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
gan: Abboud, M, et al.
Cyhoeddwyd: (2018)

Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding
gan: Thinnes, C, et al.
Cyhoeddwyd: (2018)

Mechanism of molecular oxygen diffusion in a hypoxia-sensing prolyl hydroxylase using multiscale simulation
gan: Domene, C, et al.
Cyhoeddwyd: (2020)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
gan: Lippl, K
Cyhoeddwyd: (2018)

Bioeffects of Prunus spinosa L. fruit ethanol extract on reproduction and phenotypic plasticity of Trichoplax adhaerens Schulze, 1883 (Placozoa)
gan: Maria Cristina Albertini, et al.
Cyhoeddwyd: (2019-04-01)

Trichoplax adhaerens reveals a network of nuclear receptors sensitive to 9-cis-retinoic acid at the base of metazoan evolution
gan: Jan Philipp Novotný, et al.
Cyhoeddwyd: (2017-09-01)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
gan: Cockman, M, et al.
Cyhoeddwyd: (2019)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
gan: Yeh, TL, et al.
Cyhoeddwyd: (2017)

A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation
gan: Li, Z, et al.
Cyhoeddwyd: (2020)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
gan: Chan, M, et al.
Cyhoeddwyd: (2016)

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
gan: Figg, WD, et al.
Cyhoeddwyd: (2023)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)
gan: Chowdhury, R, et al.
Cyhoeddwyd: (2011)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
gan: Chowdhury, R, et al.
Cyhoeddwyd: (2011)

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
gan: Tarhonskaya, H, et al.
Cyhoeddwyd: (2014)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
gan: Chowdhury, R, et al.
Cyhoeddwyd: (2016)

BIOL 56-ESI-MS studies on prolyl hydroxylase domain 2
gan: Mecinovic, J, et al.
Cyhoeddwyd: (2008)

Structural and mechanistic studies on prolyl hydroxylases
gan: Chowdhury, R
Cyhoeddwyd: (2008)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
gan: Astuti, D, et al.
Cyhoeddwyd: (2010)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
gan: Matthew E Cockman, et al.
Cyhoeddwyd: (2019-09-01)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
gan: Chowdhury, R, et al.
Cyhoeddwyd: (2013)