Hydrogen borrowing catalysis using 1° and 2° alcohols: investigation and scope leading to α and β branched products

The alkylation of a variety of ketones using 1° or 2° alcohols under hydrogen borrowing catalysis is described. Initial research focused on the α-alkylation of cyclopropyl ketones with higher 1° alcohols (i.e. larger than MeOH), leading to the formation of α-branched products. Our search for additio...

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Bibliographic Details
Main Authors: Frost, JR, Cheong, CB, Akhtar, WM, Caputo, DFJ, Christensen, KE, Stevenson, NG, Donohoe, TJ
Format: Journal article
Language:English
Published: Elsevier 2021