The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing Bisphosphonates

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Dunford, J, Pilka, E, Kwaasi, A, Evdokimov, A, Barnett, B, Oppermann, U, Ebetino, F, Russell, R, Kavanagh, K
Μορφή:	Conference item
Έκδοση:	2008

Evidence for the involvement of the threonine 201 side-chain in the interaction of nitrogen-containing bisphosphonates with farnesyl pyrophosphate synthase
ανά: Kwassi, A, κ.ά.
Έκδοση: (2009)

Interaction of the active site threonine 201 sidechain with the nitrogen of nttrogen-containing bisphosphonates is not essential for slow tight inhibition to farnesyl pyrophosphate synthase
ανά: Dunford, J, κ.ά.
Έκδοση: (2008)

The interaction of sidechain nitrogen with active site threonine is not essential for inhibition of farnesyl pyrophosphate synthase by nitrogen containing bisphosphonates
ανά: Dunford, J, κ.ά.
Έκδοση: (2008)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants
ανά: Tsoumpra, MK, κ.ά.
Έκδοση: (2015)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.
ανά: Tsoumpra, M, κ.ά.
Έκδοση: (2015)

Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase
ανά: Dunford, J, κ.ά.
Έκδοση: (2008)

Analysis of the kinetic mechanism of inhibition of Farnesyl Pyrophosphate Synthase by nitrogen containing bisphosphonates.
ανά: Dunford, J, κ.ά.
Έκδοση: (2006)

The mode of binding of nitrogen containing bisphosphonates in farnesyl pyrophosphate synthase
ανά: Ebetino, F, κ.ά.
Έκδοση: (2007)

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.
ανά: Dunford, J, κ.ά.
Έκδοση: (2008)

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
ανά: Dunford, J, κ.ά.
Έκδοση: (2007)

Designed mutants of human farnesyl pyrophosphate synthase (FPPS) help to characterise the interactions of nitrogen-containing bisphosphonates with Tyrosine 204 and Phenylalanine 239 side-chain residues
ανά: Tsoumpra, M, κ.ά.
Έκδοση: (2010)

Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates
ανά: Dunford, J, κ.ά.
Έκδοση: (2006)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
ανά: Ebetino, F, κ.ά.
Έκδοση: (2006)

Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase
ανά: Ebetino, F, κ.ά.
Έκδοση: (2005)

MEDI 73-Modeling, synthetic, crystallographic, and activity studies of novel bisphosphonates as inhibitors of farnesyl pyrophosphate synthase
ανά: Hogan, J, κ.ά.
Έκδοση: (2007)

Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates
ανά: Evdokimov, A, κ.ά.
Έκδοση: (2006)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
ανά: Ebetino, F, κ.ά.
Έκδοση: (2006)

A mirror image pair of bisphosphonate analogs further demonstrates the mode of binding of the bisphosphonates in farnesyl pyrophosphate synthase
ανά: Ebetino, F, κ.ά.
Έκδοση: (2008)

Human farnesyl diphosphate synthase (FDFS): Crystal structure and molecular interactions with Nnitrogen-containing bisphosphonates.
ανά: Kavanagh, K, κ.ά.
Έκδοση: (2005)

Modeling of bisphosphonate binding to farnesyl diphosphate synthase
ανά: Ebetino, F, κ.ά.
Έκδοση: (2002)

Stereochemical evidence of the mode of binding of nitrogen containing bisphosphonates in farnesyl diphosphate synthase
ανά: Ebetino, F, κ.ά.
Έκδοση: (2007)

Molecular modeling of the bisphosphonates (BPs) in farnesyl diphosphate (FPP) synthase. Proposed new mechanism of inhibition by potent nitrogen containing bisphosphonates (NBPs).
ανά: Ebetino, F, κ.ά.
Έκδοση: (2002)

Molecular modeling of the bisphosphonates in farnesyl diphosphate synthase. potential new details of the precise biochemical mechanism of action of potent nitrogen containing bisphosphonates
ανά: Ebetino, F, κ.ά.
Έκδοση: (2002)

New anti-candida active nitrogen-containing bisphosphonates as inhibitors of farnesyl pyrophosphate synthase Candida albicans
ανά: L. O. Metelytsia, κ.ά.
Έκδοση: (2019-05-01)

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells
ανά: Räikkönen, J, κ.ά.
Έκδοση: (2011)

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells.
ανά: Räikkönen, J, κ.ά.
Έκδοση: (2011)

Predicting the clinical potencies of bisphosphonates: Divergence of hydroxyapatite and farnesyl diphosphate synthase binding affinities
ανά: Xia, Z, κ.ά.
Έκδοση: (2007)

Nitrogen-containing bisphosphonates of varying antiresorptive potency have been co-crystallized in farnesyl diphosphate synthase and modelled to understand the key structural features involved in enzyme inhibition.
ανά: Ebetino, F, κ.ά.
Έκδοση: (2006)

Bisphosphonate affinity to hydroxyapatite and farnesyl pyrophosphate inhibitory potency, together, drive in vivo efficacy
ανά: Lundy, M, κ.ά.
Έκδοση: (2007)

Refining structure activity relationships among nitrogen containing bisphosphonates: Dissociation of mineral binding affinity and inhibitory potency on farnesyl diphosphate synthase.
ανά: Xia, Z, κ.ά.
Έκδοση: (2006)

Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective
ανά: Jaeok Park, κ.ά.
Έκδοση: (2021-01-01)

Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase
ανά: Kavanagh, K, κ.ά.
Έκδοση: (2006)

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
ανά: Kavanagh, K, κ.ά.
Έκδοση: (2006)

Nitrogen-containing bisphosphonates and prediction of their clinical potencies: Dissociation of target enzyme- and hydroxyapatite-binding affinities
ανά: Xia, Z, κ.ά.
Έκδοση: (2007)

The Successful Design Of A Novel Highly Potent Nitrogen-Containing Bisphosphonate With Lower Bone Affinity.
ανά: Ebetino, F, κ.ά.
Έκδοση: (2013)

Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells
ανά: Wei Xu, κ.ά.
Έκδοση: (2024-09-01)

Inhibition of human mevalonate kinase by allosteric inhibitors of farnesyl pyrophosphate synthase
ανά: Saman Salari, κ.ά.
Έκδοση: (2024-08-01)

Molecular Cloning and Characterisation of Farnesyl Pyrophosphate Synthase from Tripterygium wilfordii.
ανά: Yu-Jun Zhao, κ.ά.
Έκδοση: (2015-01-01)

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
ανά: Jaeok Park, κ.ά.
Έκδοση: (2017-01-01)

The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing Bisphosphonates

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