Expansion of a mutated clone: from stem cell to tumour.
Intestinal stem cells are adult, tissue-based stem cells located at the base of the intestinal crypt and are capable of regenerating all intestinal cell types. The progeny of mutated stem cells can expand to fill an entire crypt as a consequence of genetic drift, selective advantage or hitchhiking-e...
Główni autorzy: | , |
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Format: | Journal article |
Język: | English |
Wydane: |
2008
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