Pyrrolidinones derived from (S)-pyroglutamic acid. Part 3. beta-aminopyrrolidinones
The conjugate addition of activated nitrogen nucleophiles, such as hydroxylamine and hydrazine derivatives, to α, β-unsaturated bicyclic lactam 1a gave the corresponding β-amino products 9a-g in good yield and excellent diastereo- selectivity. These products can be manipulated to afford enantiopure...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2001
|
| _version_ | 1797080568648695808 |
|---|---|
| author | Chan, P Cottrell, I Moloney, M |
| author_facet | Chan, P Cottrell, I Moloney, M |
| author_sort | Chan, P |
| collection | OXFORD |
| description | The conjugate addition of activated nitrogen nucleophiles, such as hydroxylamine and hydrazine derivatives, to α, β-unsaturated bicyclic lactam 1a gave the corresponding β-amino products 9a-g in good yield and excellent diastereo- selectivity. These products can be manipulated to afford enantiopure β-aminopyrrolidinones of potential application as conformationally-constrained, substituted glutamate templates of well-defined stereochemistry. |
| first_indexed | 2024-03-07T01:02:00Z |
| format | Journal article |
| id | oxford-uuid:8a0abf1f-bce3-4049-804c-cd04ec8eb4a3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:02:00Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:8a0abf1f-bce3-4049-804c-cd04ec8eb4a32022-03-26T22:28:43ZPyrrolidinones derived from (S)-pyroglutamic acid. Part 3. beta-aminopyrrolidinonesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8a0abf1f-bce3-4049-804c-cd04ec8eb4a3EnglishSymplectic Elements at Oxford2001Chan, PCottrell, IMoloney, MThe conjugate addition of activated nitrogen nucleophiles, such as hydroxylamine and hydrazine derivatives, to α, β-unsaturated bicyclic lactam 1a gave the corresponding β-amino products 9a-g in good yield and excellent diastereo- selectivity. These products can be manipulated to afford enantiopure β-aminopyrrolidinones of potential application as conformationally-constrained, substituted glutamate templates of well-defined stereochemistry. |
| spellingShingle | Chan, P Cottrell, I Moloney, M Pyrrolidinones derived from (S)-pyroglutamic acid. Part 3. beta-aminopyrrolidinones |
| title | Pyrrolidinones derived from (S)-pyroglutamic acid. Part 3. beta-aminopyrrolidinones |
| title_full | Pyrrolidinones derived from (S)-pyroglutamic acid. Part 3. beta-aminopyrrolidinones |
| title_fullStr | Pyrrolidinones derived from (S)-pyroglutamic acid. Part 3. beta-aminopyrrolidinones |
| title_full_unstemmed | Pyrrolidinones derived from (S)-pyroglutamic acid. Part 3. beta-aminopyrrolidinones |
| title_short | Pyrrolidinones derived from (S)-pyroglutamic acid. Part 3. beta-aminopyrrolidinones |
| title_sort | pyrrolidinones derived from s pyroglutamic acid part 3 beta aminopyrrolidinones |
| work_keys_str_mv | AT chanp pyrrolidinonesderivedfromspyroglutamicacidpart3betaaminopyrrolidinones AT cottrelli pyrrolidinonesderivedfromspyroglutamicacidpart3betaaminopyrrolidinones AT moloneym pyrrolidinonesderivedfromspyroglutamicacidpart3betaaminopyrrolidinones |