Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

Recent studies reveal that airway epithelial cells are critical pulmonary circadian pacemaker cells, mediating rhythmic inflammatory responses. Using mouse models, we now identify the rhythmic circadian repressor REV-ERBα as essential to the mechanism coupling the pulmonary clock to innate immunity,...

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Bibliographic Details
Main Authors: Pariollaud, M, Gibbs, J, Hopwood, T, Brown, S, Begley, N, Vonslow, R, Poolman, T, Guo, B, Saer, B, Jones, D, Tellam, J, Bresciani, S, Tomkinson, N, Wojno-Picon, J, Cooper, A, Daniels, D, Trump, R, Grant, D, Zuercher, W, Willson, T, Macdonald, A, Bolognese, B, Podolin, P, Sanchez, Y, Loudon, A, Ray, D
Format: Journal article
Language:English
Published: American Society for Clinical Investigation 2018

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