Improved quantification of HIV-1-infected CD4+ T cells using an optimised method of intracellular HIV-1 gag p24 antigen detection.

The capacity of CD8+ T cells to inhibit HIV-1 replication in vitro strongly correlates with virus control in vivo. Post-hoc evaluations of HIV-1 vaccine candidates suggest that this immunological parameter is a promising benchmark of vaccine efficacy. Large-scale analysis of CD8+ T cell antiviral ac...

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Bibliographic Details
Main Authors: Yang, H, Yorke, E, Hancock, G, Clutton, G, Sande, N, Angus, B, Smyth, R, Mak, J, Dorrell, L
Format: Journal article
Language:English
Published: 2013