Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses
A missense C1858T single nucleotide polymorphism within PTPN22 is a strong genetic risk factor for the development of multiple autoimmune diseases. PTPN22 encodes a protein tyrosine phosphatase that negatively regulates immuno-receptor proximal Src and Syk family kinases. Notably, PTPN22 negatively...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Elsevier
2018
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