Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins

Histone Nε-lysine methylation is a widespread posttranslational modification that is specifically recognised by a diverse class of Nε-methyllysine binding reader proteins. Combined thermodynamic data, molecular dynamics simulations, and quantum chemical studies reveal that reader proteins efficientl...

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Hlavní autoři: Al Temimi, A, Belle, R, Kumar, K, Poater, J, Betlem, P, Pieters, B, Paton, R, Bickelhaupt, F, Mecinović, J
Médium: Journal article
Jazyk:English
Vydáno: Royal Society of Chemistry 2018