Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192...

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Hlavní autoři: Surendran, P, Drenos, F, Young, R, Warren, H, Cook, J, Manning, A, Grarup, N, Sim, X, Barnes, D, Witkowska, K, Staley, J, Tragante, V, Tukiainen, T, Yaghootkar, H, Masca, N, Freitag, D, Ferreira, T, Giannakopoulou, O, Tinker, A, Harakalova, M, Mihailov, E, Liu, C, Kraja, A, Nielsen, S, Rasheed, A, Samuel, M, Zhao, W, Bonnycastle, L, Jackson, A, Narisu, N, Swift, A, Southam, L, Marten, J, Huyghe, J, Stančáková, A, Fava, C, Ohlsson, T, Matchan, A, Stirrups, K, Bork-Jensen, J, Gjesing, A, Kontto, J, Perola, M, Shaw-Hawkins, S, Havulinna, A, Zhang, H, Donnelly, L, Groves, C, Rayner, N, Neville, M, Robertson, N, Yiorkas, A, Herzig, K, Kajantie, E, Zhang, W, Willems, S, Lannfelt, L, Malerba, G, Soranzo, N, Trabetti, E, Verweij, N, Evangelou, E, Moayyeri, A, Vergnaud, A, Nelson, C, Poveda, A, Varga, T, Caslake, M, de Craen, A, Trompet, S, Luan, J, Scott, R, Harris, S, Liewald, D, Marioni, R, Menni, C, Farmaki, A, Hallmans, G, Renström, F, Huffman, J, Hassinen, M, Burgess, S, Vasan, R, Felix, J, Uria-Nickelsen, M, Malarstig, A, Reilly, D, Hoek, M, Vogt, T, Lin, H, Lieb, W, Traylor, M, Markus, H, Highland, H, Justice, A, Marouli, E, Lindström, J, Uusitupa, M, Komulainen, P, Lakka, T, Rauramaa, R, Polasek, O, Rudan, I, Rolandsson, O, Franks, P, Dedoussis, G, Spector, T, Jousilahti, P, Männistö, S, Deary, I, Starr, J, Langenberg, C, Wareham, N, Brown, M, Dominiczak, A, Connell, J, Jukema, J, Sattar, N, Ford, I, Packard, C, Esko, T, Mägi, R, Metspalu, A, de Boer, R, van der Meer, P, van der Harst, P, Gambaro, G, Ingelsson, E, Lind, L, de Bakker, P, Numans, M, Brandslund, I, Christensen, C, Petersen, E, Korpi-Hyövälti, E, Oksa, H, Chambers, J, Kooner, J, Blakemore, A, Franks, S, Jarvelin, M, Husemoen, L, Linneberg, A, Skaaby, T, Thuesen, B, Karpe, F, Tuomilehto, J, Doney, A, Morris, A, Palmer, C, Holmen, O, Hveem, K, Willer, C, Tuomi, T, Groop, L, Käräjämäki, A, Palotie, A, Ripatti, S, Salomaa, V, Alam, D, Majumder, A, Di Angelantonio, E, Chowdhury, R, McCarthy, M, Poulter, N, Stanton, A, Sever, P, Amouyel, P, Arveiler, D, Blankenberg, S, Ferrières, J, Kee, F, Kuulasmaa, K, Müller-Nurasyid, M, Veronesi, G, Virtamo, J, Deloukas, P, Elliott, P, Zeggini, E, Kathiresan, S, Melander, O, Kuusisto, J, Laakso, M, Padmanabhan, S, Porteous, D, Hayward, C, Scotland, G, Collins, F, Mohlke, K, Hansen, T, Pedersen, O, Boehnke, M, Stringham, H, Frossard, P, Newton-Cheh, C, Tobin, M, Nordestgaard, B, Caulfield, M, Mahajan, A, Tomaszewski, M, Samani, N, Saleheen, D, Asselbergs, F, Lindgren, C, Danesh, J, Wain, L, Butterworth, A, Howson, J, Munroe, P
Médium: Journal article
Jazyk:English
Vydáno: Nature Publishing Group 2016