Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

The kinetics of the immune changes in COVID-19 across severity groups have not been rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine analysis, we analyzed serial samples from 207 SARS-CoV2-infected individuals with a range of disease severities over 12 weeks from symp...

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Bibliographic Details
Main Authors:	Bergamaschi, L, Mescia, F, Turner, L, Hanson, AL, Kotagiri, P, Dunmore, BJ, Ruffieux, H, De Sa, A, Huhn, O, Morgan, MD, Gerber, PP, Wills, MR, Baker, S, Calero-Nieto, FJ, Doffinger, R, Dougan, G, Elmer, A, Goodfellow, IG, Gupta, RK, Hosmillo, M, Hunter, K, Kingston, N, Lehner, PJ, Matheson, NJ, Nicholson, JK, Petrunkina, AM, Richardson, S, Saunders, C, Thaventhiran, JED, Toonen, EJM, Weekes, MP, Göttgens, B, Toshner, M, Hess, C, Bradley, JR, Lyons, PA, Smith, KGC
Other Authors:	Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration
Format:	Journal article
Language:	English
Published:	Cell Press 2021

Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

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