Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ES cells

<p>The Polycomb repressive complexes PRC1 and PRC2 are key mediators of heritable gene silencing in multicellular organisms. Here we characterise AEBP2, a known PRC2 cofactor which, in vitro, has been shown to stimulate PRC2 activity. We show that AEBP2 localises specifical...

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Bibliographic Details
Main Authors: Grijzenhout, A, Godwin, J, Koseki, H, Gdula, M, Szumska, D, McGouran, J, Bhattacharya, S, Kessler, B, Brockdorff, N, Cooper, S
Format: Journal article
Published: Company of Biologists 2016