11β-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation

<p>Muscle wasting is a common feature of inflammatory myopathies. Glucocorticoids (GCs), although effective at suppressing inflammation and inflammatory muscle loss, also cause myopathy with prolonged administration. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a bidirectional GC-acti...

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Bibliographic Details
Main Authors: Hardy, RS, Doig, CL, Hussain, Z, O'Leary, M, Morgan, SA, Pearson, MJ, Naylor, A, Jones, SW, Filer, A, Stewart, PM, Buckley, CD, Lavery, GG, Cooper, MS, Raza, K
Format: Journal article
Published: Wiley 2016