High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1.

Transforming growth factor-β (TGF-β) is an inducer of type I collagen, and uncontrolled collagen production leads to tissue scarring and organ failure. Here we hypothesize that uncovering a molecular mechanism that enables us to switch off type I collagen may prove beneficial in treating fibrosis. F...

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Detaylı Bibliyografya
Asıl Yazarlar: Fragiadaki, M, Ikeda, T, Witherden, A, Mason, R, Abraham, D, Bou-Gharios, G
Materyal Türü: Journal article
Dil:English
Baskı/Yayın Bilgisi: 2011