High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1.

Transforming growth factor-β (TGF-β) is an inducer of type I collagen, and uncontrolled collagen production leads to tissue scarring and organ failure. Here we hypothesize that uncovering a molecular mechanism that enables us to switch off type I collagen may prove beneficial in treating fibrosis. F...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Fragiadaki, M, Ikeda, T, Witherden, A, Mason, R, Abraham, D, Bou-Gharios, G
Μορφή: Journal article
Γλώσσα:English
Έκδοση: 2011