Ligand-dependent downregulation of MR1 cell surface expression

The antigen-presenting molecule MR1 presents riboflavin-based metabolites to Mucosal-Associated Invariant T (MAIT) cells. While MR1 egress to the cell surface is ligand-dependent, the ability of small-molecule ligands to impact on MR1 cellular trafficking remains unknown. Arising from an in silico s...

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Bibliografische gegevens
Hoofdauteurs: Salio, M, Awad, W, Veerapen, N, Gonzalez-Lopez, C, Kulicke, C, Waithe, D, Martens, AWJ, Lewinsohn, DM, Hobrath, JV, Cox, LR, Rossjohn, J, Besra, GS, Cerundolo, V
Formaat: Journal article
Taal:English
Gepubliceerd in: National Academy of Sciences 2020