Whole genome sequencing of hepatitis B virus using tiled amplicon (HEPTILE) and probe based enrichment on Illumina and Nanopore platforms

Hepatitis B virus (HBV) whole genome sequencing (WGS) is currently limited as the DNA viral loads (VL) of many clinical samples are below the threshold required to generate full genomes using current sequencing methods. We developed two pan-genotypic viral enrichment methods, using probe-based captu...

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Bibliographic Details
Main Authors:	Lumley, SF, Kent, C, Jennings, D, Chai, H, Airey, G, Waddilove, E, Delphin, M, Trebes, A, McNaughton, AL, Mohammed, KS, Wilkinson, SAJ, Wu, Y, MacIntyre-Cockett, G, Kimono, B, Mbonye, KM, Ojambo, K, Maponga, TG, Tan, CCS, de Lara, C, Martin, J, Campbell, J, Van Schalkwyk, M, Goedhals, D, Newton, R, Barnes, E, Piazza, P, Ansari, MA
Format:	Journal article
Language:	English
Published:	Nature Research 2025

Whole genome sequencing of hepatitis B virus using tiled amplicon (HEPTILE) and probe based enrichment on Illumina and Nanopore platforms

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