Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background

Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background

The emergence of Plasmodium falciparum parasites resistant to artemisinins compromises the efficacy of Artemisinin Combination Therapies (ACTs), the global first-line malaria treatment. Artemisinin resistance is a complex genetic trait in which nonsynonymous SNPs in PfK13 cooperate with other geneti...

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Detalhes bibliográficos
Principais autores: Nayak, S, Peto, TJ, Kucharski, M, Tripura, R, Callery, JJ, Quang Huy, DT, Gendrot, M, Lek, D, Nghia, HDT, van der Pluijm, RW, Dong, N, Long, LT, Vongpromek, R, Rekol, H, Hoang Chau, N, Miotto, O, Mukaka, M, Dhorda, M, von Seidlein, L, Imwong, M, Roca, X, Day, NPJ, White, NJ, Dondorp, AM
Formato: Journal article
Idioma:English
Publicado em: Nature Research 2024

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