Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background

Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background

The emergence of Plasmodium falciparum parasites resistant to artemisinins compromises the efficacy of Artemisinin Combination Therapies (ACTs), the global first-line malaria treatment. Artemisinin resistance is a complex genetic trait in which nonsynonymous SNPs in PfK13 cooperate with other geneti...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Nayak, S, Peto, TJ, Kucharski, M, Tripura, R, Callery, JJ, Quang Huy, DT, Gendrot, M, Lek, D, Nghia, HDT, van der Pluijm, RW, Dong, N, Long, LT, Vongpromek, R, Rekol, H, Hoang Chau, N, Miotto, O, Mukaka, M, Dhorda, M, von Seidlein, L, Imwong, M, Roca, X, Day, NPJ, White, NJ, Dondorp, AM
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Nature Research 2024

Những quyển sách tương tự

Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background
Bằng: Nayak, Sourav, et al.
Được phát hành: (2025)

Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background
Bằng: Sourav Nayak, et al.
Được phát hành: (2024-12-01)

Triple therapy with artemether-lumefantrine plus amodiaquine versus artemether-lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, randomised, multicentre trial
Bằng: Peto, TJ, et al.
Được phát hành: (2022)

Is triple artemisinin-based combination therapy necessary for uncomplicated malaria?
Bằng: van der Pluijm, RW, et al.
Được phát hành: (2022)

Triple artemisinin-based combination therapies for malaria – a new paradigm?
Bằng: van der Pluijm, RW, et al.
Được phát hành: (2020)

Study protocol: an open-label individually randomised controlled trial to assess the efficacy of artemether-lumefantrine prophylaxis for malaria among forest goers in Cambodia
Bằng: Maude, RJ, et al.
Được phát hành: (2021)

The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong Subregion: a molecular epidemiology observational study
Bằng: Imwong, M, et al.
Được phát hành: (2017)

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
Bằng: Zhu, L, et al.
Được phát hành: (2022)

The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response
Bằng: Zhu, L, et al.
Được phát hành: (2021)

Comparing the roles of community health workers for malaria control and elimination in Cambodia and Tanzania
Bằng: Arjen M Dondorp, et al.
Được phát hành: (2023-12-01)

Study protocol: an open-label individually randomised controlled trial to assess the efficacy of artemether-lumefantrine prophylaxis for malaria among forest goers in Cambodia
Bằng: Mavuto Mukaka, et al.
Được phát hành: (2021-07-01)

Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia.
Bằng: Mukherjee, A, et al.
Được phát hành: (2017)

Polymorphisms in Pvkelch12 and gene amplification of Pvplasmepsin4 in plasmodium vivax from Thailand, Lao PDR and Cambodia
Bằng: Duanguppama, J, et al.
Được phát hành: (2019)

Artemisinin-resistant malaria in Africa demands urgent action
Bằng: Dhorda, M, et al.
Được phát hành: (2024)

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia.
Bằng: Miotto, O, et al.
Được phát hành: (2013)

Deploying triple artemisinin-based combination therapy (TACT) for malaria treatment in Africa: ethical and practical considerations
Bằng: Tindana, P, et al.
Được phát hành: (2021)

Submicroscopic Plasmodium prevalence in relation to malaria incidence in 20 villages in western Cambodia.
Bằng: Tripura, R, et al.
Được phát hành: (2017)

Assessment in vitro of the antimalarial and transmission-blocking activities of cipargamin and ganaplacide in artemisinin-resistant Plasmodium falciparum
Bằng: Yipsirimetee, A, et al.
Được phát hành: (2022)

Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia
Bằng: Angana Mukherjee, et al.
Được phát hành: (2017-05-01)

Effectiveness and safety of 3 and 5 day courses of artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in an area of emerging artemisinin resistance in Myanmar
Bằng: Tun, KM, et al.
Được phát hành: (2018)

The probability of a sequential Plasmodium vivax infection following asymptomatic Plasmodium falciparum and P. vivax infections in Myanmar, Vietnam, Cambodia, and Laos
Bằng: Von Seidlein, L, et al.
Được phát hành: (2019)

Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia.
Bằng: Witkowski, B, et al.
Được phát hành: (2013)

High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia.
Bằng: Anderson, T, et al.
Được phát hành: (2010)

Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial
Bằng: Miotto, O, et al.
Được phát hành: (2020)

Evolution of multidrug resistance in Plasmodium falciparum: A longitudinal study of genetic resistance markers in the Greater Mekong subregion
Bằng: Imwong, M, et al.
Được phát hành: (2021)

A multi-level spatial analysis of clinical malaria and subclinical Plasmodium infections in Pailin Province, Cambodia
Bằng: Parker, D, et al.
Được phát hành: (2017)

In vitro phenotype of reduced susceptibility to artemisinin in Plasmodium falciparum isolates from western Cambodia
Bằng: Witkowski, B, et al.
Được phát hành: (2012)

The feasibility and acceptability of mass drug administration for malaria in Cambodia: a mixed-methods study
Bằng: Peto, T, et al.
Được phát hành: (2018)

Polymorphisms in Pvkelch12 and gene amplification of Pvplasmepsin4 in Plasmodium vivax from Thailand, Lao PDR and Cambodia
Bằng: Jureeporn Duanguppama, et al.
Được phát hành: (2019-04-01)

History of malaria treatment as a predictor of subsequent subclinical parasitaemia: a cross-sectional survey and malaria case records from three villages in Pailin, western Cambodia.
Bằng: Peto, T, et al.
Được phát hành: (2016)

Glucose 6 Phosphate Dehydrogenase (G6PD) quantitation using biosensors at the point of first contact: a mixed method study in Cambodia
Bằng: Bipin Adhikari, et al.
Được phát hành: (2022-10-01)

The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia
Bằng: Day Nicholas PJ, et al.
Được phát hành: (2009-02-01)

Tools to accelerate falciparum malaria elimination in Cambodia: a meeting report
Bằng: Lek, D, et al.
Được phát hành: (2020)

A controlled trial of mass drug administration to interrupt transmission of multi drug resistant falciparum malaria in Cambodian villages
Bằng: Tripura, R, et al.
Được phát hành: (2018)

Advancing artemisinin resistance monitoring using a high sensitivity ddPCR assay for Pfkelch13 mutation detection in Asia
Bằng: Srisutham, S, et al.
Được phát hành: (2025)

The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia.
Bằng: Maude, R, et al.
Được phát hành: (2009)

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
Bằng: Zhu, Lei, et al.
Được phát hành: (2022)

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
Bằng: Lei Zhu, et al.
Được phát hành: (2022-03-01)

Expanding the role of village malaria workers in Cambodia: Implementation and evaluation of four health education packages.
Bằng: Mipharny Betrian, et al.
Được phát hành: (2023-01-01)

Glucose-6-Phosphate Dehydrogenase (G6PD) Measurement Using Biosensors by Community-Based Village Malaria Workers and Hospital Laboratory Staff in Cambodia: A Quantitative Study
Bằng: Bipin Adhikari, et al.
Được phát hành: (2023-03-01)