Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance

Due to compromised homologous recombination (HR) repair, BRCA1- and BRCA2-mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour progression. To identify drugs that target specifically BRCA2-deficient cells, we screened a chemical library containing compounds in clinica...

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Bibliographic Details
Main Authors:	Tacconi, E, Badie, S, De Gregoriis, G, Reisländer, T, Lai, X, Porru, M, Folio, C, Moore, J, Kopp, A, Baguña Torres, J, Sneddon, D, Green, M, Dedic, S, Lee, J, Batra, A, Rueda, O, Bruna, A, Leonetti, C, Caldas, C, Cornelissen, B, Brino, L, Ryan, A, Biroccio, A, Tarsounas, M
Format:	Journal article
Language:	English
Published:	EMBO Press 2019

Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance

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