The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor binding

The interaction between the T cell antigen receptor (TCR) and antigenic peptide in complex with major histocompatibility complex (MHC) molecules is a crucial step in T cell activation. The relative contributions of TCR:peptide and TCR:MHC contacts to the overall binding energy remain unclear. Thi...

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Váldodahkkit: Zhang, H, Lim, H, Knapp, B, Deane, C, Aleksic, M, Dushek, O, van der Merwe, P
Materiálatiipa: Journal article
Almmustuhtton: Nature Publishing Group 2016