The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor binding

The interaction between the T cell antigen receptor (TCR) and antigenic peptide in complex with major histocompatibility complex (MHC) molecules is a crucial step in T cell activation. The relative contributions of TCR:peptide and TCR:MHC contacts to the overall binding energy remain unclear. Thi...

詳細記述

書誌詳細
主要な著者: Zhang, H, Lim, H, Knapp, B, Deane, C, Aleksic, M, Dushek, O, van der Merwe, P
フォーマット: Journal article
出版事項: Nature Publishing Group 2016