Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
Two isoforms of the enzyme 11beta-hydroxysteroid dehydrogenase (11beta-HSD) interconvert the active glucocorticoid, cortisol, and inactive cortisone. 11beta-HSD1 is believed to act in vivo predominantly as an oxo-reductase using NADP(H) as a cofactor to generate cortisol. In contrast, 11beta-HSD2 ac...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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