Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra.

The presynaptic protein α-synuclein is central to the pathogenesis of α-synucleinopathies. We show that the presence of endogenous mouse α-synuclein leads to higher number of dopaminergic neurons in the substantia nigra of wild-type C57Bl/6J mice compared with C57Bl/6S mice with a spontaneous deleti...

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Bibliographic Details
Main Authors: Garcia-Reitboeck, P, Anichtchik, O, Dalley, J, Ninkina, N, Tofaris, G, Buchman, V, Spillantini, MG
Format: Journal article
Language:English
Published: 2013