Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra.
The presynaptic protein α-synuclein is central to the pathogenesis of α-synucleinopathies. We show that the presence of endogenous mouse α-synuclein leads to higher number of dopaminergic neurons in the substantia nigra of wild-type C57Bl/6J mice compared with C57Bl/6S mice with a spontaneous deleti...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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| _version_ | 1826284323206070272 |
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| author | Garcia-Reitboeck, P Anichtchik, O Dalley, J Ninkina, N Tofaris, G Buchman, V Spillantini, MG |
| author_facet | Garcia-Reitboeck, P Anichtchik, O Dalley, J Ninkina, N Tofaris, G Buchman, V Spillantini, MG |
| author_sort | Garcia-Reitboeck, P |
| collection | OXFORD |
| description | The presynaptic protein α-synuclein is central to the pathogenesis of α-synucleinopathies. We show that the presence of endogenous mouse α-synuclein leads to higher number of dopaminergic neurons in the substantia nigra of wild-type C57Bl/6J mice compared with C57Bl/6S mice with a spontaneous deletion of the α-synuclein gene or C57Bl/6J mice with a targeted deletion of the α-synuclein gene. This effect of α-synuclein on dopaminergic neuron occurs during development between E10.5 and E13.5 and persists in adult life supporting the involvement of α-synuclein in the development of a subset of dopaminergic neurons. |
| first_indexed | 2024-03-07T01:12:07Z |
| format | Journal article |
| id | oxford-uuid:8d604450-67f0-481b-bc57-64958f16cf53 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:12:07Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:8d604450-67f0-481b-bc57-64958f16cf532022-03-26T22:50:51ZEndogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8d604450-67f0-481b-bc57-64958f16cf53EnglishSymplectic Elements at Oxford2013Garcia-Reitboeck, PAnichtchik, ODalley, JNinkina, NTofaris, GBuchman, VSpillantini, MGThe presynaptic protein α-synuclein is central to the pathogenesis of α-synucleinopathies. We show that the presence of endogenous mouse α-synuclein leads to higher number of dopaminergic neurons in the substantia nigra of wild-type C57Bl/6J mice compared with C57Bl/6S mice with a spontaneous deletion of the α-synuclein gene or C57Bl/6J mice with a targeted deletion of the α-synuclein gene. This effect of α-synuclein on dopaminergic neuron occurs during development between E10.5 and E13.5 and persists in adult life supporting the involvement of α-synuclein in the development of a subset of dopaminergic neurons. |
| spellingShingle | Garcia-Reitboeck, P Anichtchik, O Dalley, J Ninkina, N Tofaris, G Buchman, V Spillantini, MG Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra. |
| title | Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra. |
| title_full | Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra. |
| title_fullStr | Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra. |
| title_full_unstemmed | Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra. |
| title_short | Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra. |
| title_sort | endogenous alpha synuclein influences the number of dopaminergic neurons in mouse substantia nigra |
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