Normalizing gas‐chromatography–mass spectrometry data: method choice can alter biological inference

We demonstrate how different normalization techniques in GC‐MS analysis impart unique properties to the data, influencing any biological inference. Using simulations, and empirical data, we compare the most commonly used techniques (Total Sum Normalization ‘TSN’; Median Normalization ‘MN’; Probabili...

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Bibliographic Details
Main Authors: Noonan, M, Tinnesand, H, Buesching, C
Format: Journal article
Published: Wiley 2018