Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.

HIF prolyl hydroxylases (PHD1-3) are oxygen sensors that regulate the stability of the hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we show that loss of Phd1 lowers oxygen consumption in skeletal muscle by reprogramming glucose metabolism from oxidative to more anaerobic ATP...

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Bibliographic Details
Main Authors:	Aragonés, J, Schneider, M, Van Geyte, K, Fraisl, P, Dresselaers, T, Mazzone, M, Dirkx, R, Zacchigna, S, Lemieux, H, Jeoung, N, Lambrechts, D, Bishop, T, Lafuste, P, Diez-Juan, A, Harten, S, Van Noten, P, De Bock, K, Willam, C, Tjwa, M, Grosfeld, A, Navet, R, Moons, L, Vandendriessche, T, Deroose, C, Wijeyekoon, B
Format:	Journal article
Language:	English
Published:	2008

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.

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