Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.

HIF prolyl hydroxylases (PHD1-3) are oxygen sensors that regulate the stability of the hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we show that loss of Phd1 lowers oxygen consumption in skeletal muscle by reprogramming glucose metabolism from oxidative to more anaerobic ATP...

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Bibliographic Details
Main Authors: Aragonés, J, Schneider, M, Van Geyte, K, Fraisl, P, Dresselaers, T, Mazzone, M, Dirkx, R, Zacchigna, S, Lemieux, H, Jeoung, N, Lambrechts, D, Bishop, T, Lafuste, P, Diez-Juan, A, Harten, S, Van Noten, P, De Bock, K, Willam, C, Tjwa, M, Grosfeld, A, Navet, R, Moons, L, Vandendriessche, T, Deroose, C, Wijeyekoon, B
Format: Journal article
Language:English
Published: 2008

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