Prevention of diabetes but not insulitis in NOD mice injected with antibody to CD4.
Non-obese diabetic (NOD) mice were injected with a rat monoclonal antibody to CD4 from birth every two weeks through 6 months of age. These animals gained weight normally but < 11% of their spleen T cells were CD4+, compared with 28% of CD4+ in controls injected with polyclonal rat IgG. The r...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1993
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