Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro.

Since in juvenile rats the liver is the predominant site of erythropoietin (EPO) gene expression, we have used primary cultures of juvenile rat hepatocytes to establish and in vitro system for investigation of oxygen-dependent EPO formation. When isolated hepatocytes were incubated at reduced oxygen...

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Bibliographic Details
Main Authors: Eckardt, K, Pugh, C, Ratcliffe, P, Kurtz, A
Format: Journal article
Language:English
Published: 1993