Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro.

Since in juvenile rats the liver is the predominant site of erythropoietin (EPO) gene expression, we have used primary cultures of juvenile rat hepatocytes to establish and in vitro system for investigation of oxygen-dependent EPO formation. When isolated hepatocytes were incubated at reduced oxygen...

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Autors principals: Eckardt, K, Pugh, C, Ratcliffe, P, Kurtz, A
Format: Journal article
Idioma:English
Publicat: 1993