Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase

Human cells utilize a variety of complex DNA repair mechanisms in order to combat constant mutagenic and cytotoxic threats from both exogenous and endogenous sources. The RecQ family of DNA helicases, which includes Bloom helicase (BLM), plays an important function in DNA repair by unwinding complem...

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Bibliographic Details
Main Authors: Rosenthal, A, Dexheimer, T, Gileadi, O, Nguyen, G, Chu, W, Hickson, I, Jadhav, A, Simeonov, A, Maloney, D
Format: Journal article
Language:English
Published: 2013