MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates

MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates

The only currently licensed vaccine against tuberculosis (TB), Bacille Calmette Guérin (BCG), is insufficient to control the epidemic. MTBVAC is a live attenuated strain of Mycobacterium tuberculosis (M.tb) and is one the most advanced TB vaccine candidates in the pipeline. It is more efficacious th...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Peralta-Álvarez, MP, Downward, K, White, A, Redondo Azema, H, Sibley, L, Sarfas, C, Morrison, A, Dennis, M, Diaz-Santana, D, Harris, SA, Li, S, Puentes, E, Aguilo, N, Martin, C, Sharpe, S, McShane, H, Tanner, R
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Nature Research 2024

Những quyển sách tương tự

MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates
Bằng: Marco Polo Peralta-Álvarez, et al.
Được phát hành: (2024-11-01)

Low-dose M.tb infection but not BCG or MTBVAC vaccination enhances heterologous antibody titres in non-human primates
Bằng: Marco Polo Peralta Alvarez, et al.
Được phát hành: (2024-05-01)

Low-dose M.tb infection but not BCG or MTBVAC vaccination enhances heterologous antibody titres in non-human primates
Bằng: Alvarez, MPP, et al.
Được phát hành: (2024)

Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis
Bằng: Alvaro Roy, et al.
Được phát hành: (2019-10-01)

Development of a non-human primate BCG infection model for the evaluation of candidate tuberculosis vaccines
Bằng: Harris, S, et al.
Được phát hành: (2017)

MTBVAC from discovery to clinical trials in tuberculosis-endemic countries
Bằng: Dessislava Marinova, et al.
Được phát hành: (2017-06-01)

Induction of functional specific antibodies, IgG-secreting plasmablasts and memory B cells following BCG vaccination
Bằng: Bitencourt, J, et al.
Được phát hành: (2021)

MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies
Bằng: Andrew D. White, et al.
Được phát hành: (2021-01-01)

Salivary anti-PGL IgM and IgA titers and serum antibody IgG titers and avidities in leprosy patients and their correlation with time of infection and antigen exposure
Bằng: Aparecida T. Nagao-Dias, et al.

MTBVAC: Attenuating the Human Pathogen of Tuberculosis (TB) Toward a Promising Vaccine against the TB Epidemic
Bằng: Jesus Gonzalo-Asensio, et al.
Được phát hành: (2017-12-01)

The humoral immune response to BCG vaccination
Bằng: Tanner, R, et al.
Được phát hành: (2019)

Immune cell population dynamics following neonatal BCG vaccination and aerosol BCG revaccination in rhesus macaques
Bằng: Laura Sibley, et al.
Được phát hành: (2024-07-01)

Revaccination with BCG: does it work?
Bằng: McShane, H
Được phát hành: (2024)

Understanding BCG is the key to improving it.
Bằng: McShane, H
Được phát hành: (2013)

Predicting IFN-γ responses after BCG vaccination in humans from macaques: A proof-of-concept study of Immunostimulation/Immunodynamic modelling methods
Bằng: Rhodes, S, et al.
Được phát hành: (2017)

Construction and characterization of recombinant MTBVAC. HIV, a new live attenuated vaccine against HIV and tuberculosis
Bằng: Saubi, N, et al.
Được phát hành: (2018)

Serological IgG avidity test for ocular toxoplasmosis
Bằng: Suresh S, et al.
Được phát hành: (2012-01-01)

Induction of Functional Specific Antibodies, IgG-Secreting Plasmablasts and Memory B Cells Following BCG Vaccination
Bằng: Julia Bitencourt, et al.
Được phát hành: (2022-01-01)

Editorial commentary: Understanding BCG is the key to improving it
Bằng: McShane, H
Được phát hành: (2014)

Development of a primate model for tuberculosis vaccine research: IFN-gamma responses induced by BCG vaccination and M-tuberculosis infection in macaques
Bằng: Dowall, S, et al.
Được phát hành: (2007)

Role of IgG avidity in eyes with active Toxoplasma retinochoroiditis
Bằng: Pratik Lakhmawar, et al.
Được phát hành: (2024-02-01)

IgG Avidity Test in Congenital Toxoplasmosis Diagnoses in Newborns
Bằng: Zulmirene Cardoso Fonseca, et al.
Được phát hành: (2017-06-01)

Diagnosis of Toxoplasmosis in Pregnant Women by IgG Avidity Assay
Bằng: M. Roozbehani, et al.
Được phát hành: (2015-02-01)

Nanoscale spatial dependence of avidity in an IgG1 antibody
Bằng: Agnieszka Jendroszek, et al.
Được phát hành: (2021-06-01)

IV BCG Vaccination and Aerosol BCG Revaccination Induce Mycobacteria-Responsive γδ T Cells Associated with Protective Efficacy against <i>M. tb</i> Challenge
Bằng: Alexandra L. Morrison, et al.
Được phát hành: (2023-10-01)

MTBVAC-based TB-HIV vaccine is safe, elicits HIV-T cell responses, and protects against Mycobacterium tuberculosis in Mice
Bằng: Broset, E, et al.
Được phát hành: (2019)

MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice
Bằng: Esther Broset, et al.
Được phát hành: (2019-06-01)

Longitudinal antibody titer, avidity, and neutralizing responses after SARS-CoV-2 infection
Bằng: Jonathon M. Monroe, et al.
Được phát hành: (2022-11-01)

EPSTEIN-BARR VIRUS INFECTIONS – AVIDITY TEST FOR IgG ANTIBODIES
Bằng: Katja Strašek, et al.
Được phát hành: (2001-06-01)

Diagnosis of Acute Toxoplasmosis in the First Trimester of Pregnancy by IgG Avidity
Bằng: Afshin Azimi, et al.
Được phát hành: (2022-06-01)

Measurement of the IgG Avidity Index in the Diagnosis of Clinical Toxocariasis Patients
Bằng: Estelle Menu, et al.
Được phát hành: (2021-08-01)

New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia.
Bằng: Raquel Tarancón, et al.
Được phát hành: (2020-04-01)

The Humoral Immune Response to BCG Vaccination
Bằng: Rachel Tanner, et al.
Được phát hành: (2019-06-01)

Indeterminate/moderate IgG avidity during HCMV infection: comparison of methods
Bằng: Massimo De Paschale, et al.
Được phát hành: (2010-03-01)

A non-human primate in vitro functional assay for the early evaluation of TB vaccine candidates
Bằng: Tanner, R, et al.
Được phát hành: (2021)

Characterization of the Infant Immune System and the Influence and Immunogenicity of BCG Vaccination in Infant and Adult Rhesus Macaques
Bằng: Charlotte Sarfas, et al.
Được phát hành: (2021-10-01)

Evaluation of a human BCG challenge model to assess antimycobacterial immunity induced by BCG and a candidate TB vaccine, MVA85A, alone and in combination
Bằng: Harris, S, et al.
Được phát hành: (2013)

Standardization and uses of IgG antibodies avidity assays in the laboratorial diagnosis of animal toxoplasmosis
Bằng: Luciana Regina Meireles
Được phát hành: (2005-08-01)

Seropositivity of Cytomegalovirus, Rubella and Toxoplasma Gondii in Pregnant Women and IgG Avidity Tests
Bằng: Cemal ÇİÇEK, et al.
Được phát hành: (2023-04-01)

Detection of persistent low IgG avidity–an interpretative problem in the diagnosis of acute toxoplasmosis
Bằng: Petr Kodym, et al.
Được phát hành: (2023-01-01)