Acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants.
Cytomegalovirus (CMV) coinfection is associated with infant HIV-1 disease progression and mortality. In a cohort of Kenyan HIV-infected infants, the frequencies of activated (CD38(+) HLA-DR(+)) and apoptosis-vulnerable (CD95(+) Bcl-2(-)) CD4(+) and CD8(+) T cells increased substantially during acute...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2012
|
| _version_ | 1826284553814147072 |
|---|---|
| author | Slyker, J Rowland-Jones, S Dong, T Reilly, M Richardson, B Emery, VC Atzberger, A Mbori-Ngacha, D Lohman-Payne, B John-Stewart, G |
| author_facet | Slyker, J Rowland-Jones, S Dong, T Reilly, M Richardson, B Emery, VC Atzberger, A Mbori-Ngacha, D Lohman-Payne, B John-Stewart, G |
| author_sort | Slyker, J |
| collection | OXFORD |
| description | Cytomegalovirus (CMV) coinfection is associated with infant HIV-1 disease progression and mortality. In a cohort of Kenyan HIV-infected infants, the frequencies of activated (CD38(+) HLA-DR(+)) and apoptosis-vulnerable (CD95(+) Bcl-2(-)) CD4(+) and CD8(+) T cells increased substantially during acute CMV infection. The frequency of activated CD4(+) T cells was strongly associated with both concurrent CMV coinfection (P = 0.001) and HIV-1 viral load (P = 0.05). The frequency of apoptosis-vulnerable cells was also associated with CMV coinfection in the CD4 (P = 0.02) and CD8 (P < 0.001) T cell subsets. Similar observations were made in HIV-exposed uninfected infants. CMV-induced increases in T cell activation and apoptosis may contribute to the rapid disease progression in coinfected infants. |
| first_indexed | 2024-03-07T01:15:34Z |
| format | Journal article |
| id | oxford-uuid:8e893d9d-11f6-469a-8fcb-b058737f8c9b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:15:34Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:8e893d9d-11f6-469a-8fcb-b058737f8c9b2022-03-26T22:58:31ZAcute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8e893d9d-11f6-469a-8fcb-b058737f8c9bEnglishSymplectic Elements at Oxford2012Slyker, JRowland-Jones, SDong, TReilly, MRichardson, BEmery, VCAtzberger, AMbori-Ngacha, DLohman-Payne, BJohn-Stewart, GCytomegalovirus (CMV) coinfection is associated with infant HIV-1 disease progression and mortality. In a cohort of Kenyan HIV-infected infants, the frequencies of activated (CD38(+) HLA-DR(+)) and apoptosis-vulnerable (CD95(+) Bcl-2(-)) CD4(+) and CD8(+) T cells increased substantially during acute CMV infection. The frequency of activated CD4(+) T cells was strongly associated with both concurrent CMV coinfection (P = 0.001) and HIV-1 viral load (P = 0.05). The frequency of apoptosis-vulnerable cells was also associated with CMV coinfection in the CD4 (P = 0.02) and CD8 (P < 0.001) T cell subsets. Similar observations were made in HIV-exposed uninfected infants. CMV-induced increases in T cell activation and apoptosis may contribute to the rapid disease progression in coinfected infants. |
| spellingShingle | Slyker, J Rowland-Jones, S Dong, T Reilly, M Richardson, B Emery, VC Atzberger, A Mbori-Ngacha, D Lohman-Payne, B John-Stewart, G Acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants. |
| title | Acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants. |
| title_full | Acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants. |
| title_fullStr | Acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants. |
| title_full_unstemmed | Acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants. |
| title_short | Acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants. |
| title_sort | acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis vulnerable t cells in hiv 1 infected infants |
| work_keys_str_mv | AT slykerj acutecytomegalovirusinfectionisassociatedwithincreasedfrequenciesofactivatedandapoptosisvulnerabletcellsinhiv1infectedinfants AT rowlandjoness acutecytomegalovirusinfectionisassociatedwithincreasedfrequenciesofactivatedandapoptosisvulnerabletcellsinhiv1infectedinfants AT dongt acutecytomegalovirusinfectionisassociatedwithincreasedfrequenciesofactivatedandapoptosisvulnerabletcellsinhiv1infectedinfants AT reillym acutecytomegalovirusinfectionisassociatedwithincreasedfrequenciesofactivatedandapoptosisvulnerabletcellsinhiv1infectedinfants AT richardsonb acutecytomegalovirusinfectionisassociatedwithincreasedfrequenciesofactivatedandapoptosisvulnerabletcellsinhiv1infectedinfants AT emeryvc acutecytomegalovirusinfectionisassociatedwithincreasedfrequenciesofactivatedandapoptosisvulnerabletcellsinhiv1infectedinfants AT atzbergera acutecytomegalovirusinfectionisassociatedwithincreasedfrequenciesofactivatedandapoptosisvulnerabletcellsinhiv1infectedinfants AT mboringachad acutecytomegalovirusinfectionisassociatedwithincreasedfrequenciesofactivatedandapoptosisvulnerabletcellsinhiv1infectedinfants AT lohmanpayneb acutecytomegalovirusinfectionisassociatedwithincreasedfrequenciesofactivatedandapoptosisvulnerabletcellsinhiv1infectedinfants AT johnstewartg acutecytomegalovirusinfectionisassociatedwithincreasedfrequenciesofactivatedandapoptosisvulnerabletcellsinhiv1infectedinfants |