Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing

Any replicating system in which heritable variants with differing replicative potentials can arise is subject to a Darwinian evolutionary process. The continually replicating adult tissue stem cells that control the integrity of many tissues of long-lived, multicellular, complex vertebrate organisms...

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Bibliographic Details
Main Authors: Bodmer, WF, Crouch, DJM
Format: Journal article
Language:English
Published: Elsevier 2020