Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing
Any replicating system in which heritable variants with differing replicative potentials can arise is subject to a Darwinian evolutionary process. The continually replicating adult tissue stem cells that control the integrity of many tissues of long-lived, multicellular, complex vertebrate organisms...
| Principais autores: | , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
Elsevier
2020
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| _version_ | 1826284556855017472 |
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| author | Bodmer, WF Crouch, DJM |
| author_facet | Bodmer, WF Crouch, DJM |
| author_sort | Bodmer, WF |
| collection | OXFORD |
| description | Any replicating system in which heritable variants with differing replicative potentials can arise is subject to a Darwinian evolutionary process. The continually replicating adult tissue stem cells that control the integrity of many tissues of long-lived, multicellular, complex vertebrate organisms, including humans, constitute such a replicating system. Our suggestion is that somatic selection for mutations (or stable epigenetic changes) that cause an increased rate of adult tissue stem cell proliferation, and their long-term persistence, at the expense of normal differentiation, is a major key to the ageing process. Once an organism has passed the reproductive age, there is no longer any significant counterselection at the organismal level to this inevitable cellular level Darwinian process. |
| first_indexed | 2024-03-07T01:15:37Z |
| format | Journal article |
| id | oxford-uuid:8e8d8942-569c-4012-aabc-5eb65d8cdeca |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:15:37Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:8e8d8942-569c-4012-aabc-5eb65d8cdeca2022-03-26T22:58:32ZSomatic selection of poorly differentiating variant stem cell clones could be a key to human ageingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8e8d8942-569c-4012-aabc-5eb65d8cdecaEnglishSymplectic ElementsElsevier2020Bodmer, WFCrouch, DJMAny replicating system in which heritable variants with differing replicative potentials can arise is subject to a Darwinian evolutionary process. The continually replicating adult tissue stem cells that control the integrity of many tissues of long-lived, multicellular, complex vertebrate organisms, including humans, constitute such a replicating system. Our suggestion is that somatic selection for mutations (or stable epigenetic changes) that cause an increased rate of adult tissue stem cell proliferation, and their long-term persistence, at the expense of normal differentiation, is a major key to the ageing process. Once an organism has passed the reproductive age, there is no longer any significant counterselection at the organismal level to this inevitable cellular level Darwinian process. |
| spellingShingle | Bodmer, WF Crouch, DJM Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing |
| title | Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing |
| title_full | Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing |
| title_fullStr | Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing |
| title_full_unstemmed | Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing |
| title_short | Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing |
| title_sort | somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing |
| work_keys_str_mv | AT bodmerwf somaticselectionofpoorlydifferentiatingvariantstemcellclonescouldbeakeytohumanageing AT crouchdjm somaticselectionofpoorlydifferentiatingvariantstemcellclonescouldbeakeytohumanageing |