Mutations in Kruppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression.

Mutations in Kruppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression.

In this study, we report on 8 compound heterozygotes for mutations in the key erythroid transcription factor Krüppel-like factor 1 in patients who presented with severe, transfusion-dependent hemolytic anemia. In most cases, the red cells were hypochromic and microcytic, consistent with abnormalitie...

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Détails bibliographiques
Auteurs principaux: Viprakasit, V, Ekwattanakit, S, Riolueang, S, Chalaow, N, Fisher, C, Lower, K, Kanno, H, Tachavanich, K, Bejrachandra, S, Saipin, J, Juntharaniyom, M, Sanpakit, K, Tanphaichitr, V, Songdej, D, Babbs, C, Gibbons, R, Philipsen, S, Higgs, D
Format: Journal article
Langue:English
Publié: American Society of Hematology 2014

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