New insights into the evolutionary rate of HIV-1 at the within-host and epidemiological levels.

Over calendar time, HIV-1 evolves considerably faster within individuals than it does at the epidemic level. This is a surprising observation since, from basic population genetic theory, we would expect the genetic substitution rate to be similar across different levels of biological organization. T...

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Bibliographic Details
Main Authors: Lythgoe, KA, Fraser, C
Format: Journal article
Language:English
Published: The Royal Society 2012