Base excision repair fidelity in normal and cancer cells.
In mammalian cells, base excision repair (BER) is the major repair pathway involved in the removal of non-bulky damaged nucleotides. The fidelity of BER is dependent on the polymerization step, where the major BER DNA polymerase (Pol beta) must incorporate the correct Watson-Crick base paired nucleo...
Main Authors: | , , |
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Format: | Journal article |
Language: | English |
Published: |
2006
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