Base excision repair fidelity in normal and cancer cells.

In mammalian cells, base excision repair (BER) is the major repair pathway involved in the removal of non-bulky damaged nucleotides. The fidelity of BER is dependent on the polymerization step, where the major BER DNA polymerase (Pol beta) must incorporate the correct Watson-Crick base paired nucleo...

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Bibliographic Details
Main Authors: Chan, K, Zhang, Q, Dianov, G
Format: Journal article
Language:English
Published: 2006