Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene.

Drug-resistant strains of herpes simplex virus type 1 (HSV-1) were selected under the pressure of (S)-3-hydroxy-2-phosphonylmethoxypropyl (HPMP) derivatives of cytosine (HPMPC, cidofovir) and adenine (HPMPA) and 2-phosphonylmethoxyethyl (PME) derivatives of adenine (PMEA, adefovir) and 2,6-diaminopu...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Andrei, G, Snoeck, R, De Clercq, E, Esnouf, R, Fiten, P, Opdenakker, G
स्वरूप: Journal article
भाषा:English
प्रकाशित: 2000