[18F]AZD2461, an insight on difference in PARP binding profiles for DNA damage response PET imaging

Purpose Poly(ADP-ribose) polymerase (PARP) inhibitors are extensively studied and used as anti-cancer drugs, as single agents or in combination with other therapies. Most radiotracers developed to date have been chosen on the basis of strong PARP1-3 affinity. Herein, we propose to study AZD2461, a P...

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Bibliographic Details
Main Authors: Guibbal, F, Hopkins, S, Pacelli, A, Isenegger, PG, Mosley, M, Torres, J, Dias, GM, Mahaut, D, Hueting, R, Gouverneur, V, Cornelissen, B
Format: Journal article
Language:English
Published: Springer Verlag 2020