Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases.
Alterations in glycosphingolipid (GSL) production results in lysosomal storage disorders associated with neurodegenerative changes. In Gaucher's disease, the patients also develop osteoporosis that is ameliorated upon treatment for the underlying defect in GSL metabolism. The role of GSLs in os...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1797081666251915264 |
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| author | Ersek, A Karadimitris, A Horwood, N |
| author_facet | Ersek, A Karadimitris, A Horwood, N |
| author_sort | Ersek, A |
| collection | OXFORD |
| description | Alterations in glycosphingolipid (GSL) production results in lysosomal storage disorders associated with neurodegenerative changes. In Gaucher's disease, the patients also develop osteoporosis that is ameliorated upon treatment for the underlying defect in GSL metabolism. The role of GSLs in osteoclast and osteoblast formation is discussed here as well as the potential therapeutic uses of already approved drugs that limit GSL production in bone loss disorders such as multiple myeloma and periodontal disease. |
| first_indexed | 2024-03-07T01:17:18Z |
| format | Journal article |
| id | oxford-uuid:8f212675-b380-420d-aeda-2756e308fa75 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:17:18Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:8f212675-b380-420d-aeda-2756e308fa752022-03-26T23:02:17ZEffect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8f212675-b380-420d-aeda-2756e308fa75EnglishSymplectic Elements at Oxford2012Ersek, AKaradimitris, AHorwood, NAlterations in glycosphingolipid (GSL) production results in lysosomal storage disorders associated with neurodegenerative changes. In Gaucher's disease, the patients also develop osteoporosis that is ameliorated upon treatment for the underlying defect in GSL metabolism. The role of GSLs in osteoclast and osteoblast formation is discussed here as well as the potential therapeutic uses of already approved drugs that limit GSL production in bone loss disorders such as multiple myeloma and periodontal disease. |
| spellingShingle | Ersek, A Karadimitris, A Horwood, N Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases. |
| title | Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases. |
| title_full | Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases. |
| title_fullStr | Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases. |
| title_full_unstemmed | Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases. |
| title_short | Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases. |
| title_sort | effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases |
| work_keys_str_mv | AT erseka effectofglycosphingolipidsonosteoclastogenesisandosteolyticbonediseases AT karadimitrisa effectofglycosphingolipidsonosteoclastogenesisandosteolyticbonediseases AT horwoodn effectofglycosphingolipidsonosteoclastogenesisandosteolyticbonediseases |