POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells
<p>POLQ is a key effector of DSB repair by microhomology-mediated end-joining (MMEJ) and is overexpressed in many cancers. POLQ inhibitors confer synthetic lethality in HR and Shieldin-deficient cancer cells, which has been proposed to reflect a critical dependence on the DSB repair pathway by...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cell Press
2022
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