POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells

POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells

<p>POLQ is a key effector of DSB repair by microhomology-mediated end-joining (MMEJ) and is overexpressed in many cancers. POLQ inhibitors confer synthetic lethality in HR and Shieldin-deficient cancer cells, which has been proposed to reflect a critical dependence on the DSB repair pathway by...

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Xehetasun bibliografikoak
Egile Nagusiak:	Belan, O, Sebald, M, Adamowicz, M, Higgins, G
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	Cell Press 2022

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