A three-in-one-bullet for oesophageal cancer: replication fork collapse, spindle attachment failure and enhanced radiosensitivity generated by a ruthenium(II) metallo-intercalator
Substitutionally inert ruthenium(ii) polypyridyl complexes have been developed as DNA intercalating agents yet cellular DNA damage responses to this binding modality are largely unexplored. Here, we show the nuclear-targeting complex [Ru(phen) 2 (tpphz)] 2+ (phen = 1,10-phenanthroline, tpphz = tetra...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Published: |
Royal Society of Chemistry
2017
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