Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair.
Many cancers display increased expression of histone deacetylases (HDACs) and therefore transcriptionally inactive chromatin, resulting in the downregulation of genes including tumour suppressor and DNA repair genes. Histone deacetylase inhibitors (HDACi) are a heterogeneous group of epigenetic ther...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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