Hydrogen‐bond‐enabled dynamic kinetic resolution of axially chiral amides mediated by a chiral counterion
Non‐biaryl atropisomers are valuable in medicine, materials, and catalysis, but their enantioselective synthesis remains a challenge. Herein, a counterion‐mediated O‐alkylation method for the generation of atropisomeric amides with an er up to 99:1 is outlined. This dynamic kinetic resolution is ena...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
John Wiley and Sons, Ltd.
2019
|