Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity

Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity

Cyclic GMP-AMP (cGAMP) is an immunostimulatory molecule produced by cGAS that activates STING. cGAMP is an adjuvant when administered alongside antigens. cGAMP is also incorporated into enveloped virus particles during budding. Here, we investigate whether inclusion of cGAMP within viral vaccine vec...

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Bibliographic Details
Main Authors: Chauveau, L, Bridgeman, A, Tan, TK, Beveridge, R, Frost, JN, Rijal, P, Pedroza-Pacheco, I, Partridge, T, Gilbert-Jaramillo, J, Knight, ML, Liu, X, Russell, RA, Borrow, P, Drakesmith, H, Townsend, AR, Rehwinkel, J
Format: Journal article
Language:English
Published: Springer 2021

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