Dichloroacetate increases cell and antibody yields in batch cultures of a hybridoma cell line.
We have studied the effect of the pyruvate dehydrogenase (PDH) activator, dichloroacetate (DCA), on the growth, metabolism, and productivity of the PQXB (1/2) hybridoma cell line. In control batch cultures, cessation of growth and the onset of decline phase coincided with the time at which the media...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1996
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