The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites

The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites

The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the current leading blood-stage malaria vaccine candidate. PfRH5 functions as part of the pentameric PCRCR complex containing PTRAMP, CSS, PfCyRPA and PfRIPR, all of which are essential for infection of human red blood cells...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Weiss, GE, Ragotte, RJ, Quinkert, D, Lias, AM, Dans, MG, Boulet, C, Looker, O, Ventura, OD, Williams, BG, Crabb, BS, Draper, SJ, Gilson, PR
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	Public Library of Science 2023

Gelijkaardige items

The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites.
door: Greta E Weiss, et al.
Gepubliceerd in: (2023-09-01)

The molecular basis of Plasmodium falciparum merozoite invasion inhibition via anti-PfCyRPA antibodies
door: Ragotte, R
Gepubliceerd in: (2020)

The essential malaria protein PfCyRPA targets glycans to invade erythrocytes
door: Christopher J. Day, et al.
Gepubliceerd in: (2024-04-01)

Targeting PfRh5 on Merozoites to Prevent Basigin Binding
door: Papadopoulos Konstantinos
Gepubliceerd in: (2012-10-01)

Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5.
door: Douglas, A, et al.
Gepubliceerd in: (2014)

Leveraging Immunofocusing and Virus-like Particle Display to Enhance Antibody Responses to the Malaria Blood-Stage Invasion Complex Antigen PfCyRPA
door: Kasper H. Björnsson, et al.
Gepubliceerd in: (2024-07-01)

Scalable Process for High-Yield Production of PfCyRPA Using Insect Cells for Inclusion in a Malaria Virosome-Based Vaccine Candidate
door: Bárbara Fernandes, et al.
Gepubliceerd in: (2022-05-01)

Antibodies targeting the PfRH1 binding domain inhibit invasion of plasmodium falciparum merozoites
door: Iyer, Jayasree K., et al.
Gepubliceerd in: (2011)

Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites.
door: Xiaohong Gao, et al.
Gepubliceerd in: (2008-07-01)

The malaria blood stage antigen PfCyRPA formulated with the TLR-4 agonist adjuvant GLA-SE elicits parasite growth inhibitory antibodies in experimental animals
door: Marco Tamborrini, et al.
Gepubliceerd in: (2023-07-01)

Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domains.
door: Tony Triglia, et al.
Gepubliceerd in: (2011-06-01)

Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens.
door: Williams, A, et al.
Gepubliceerd in: (2012)

Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens.
door: Andrew R Williams, et al.
Gepubliceerd in: (2012-01-01)

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5
door: Harrison, TE, et al.
Gepubliceerd in: (2024)

A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants
door: Bustamante, L, et al.
Gepubliceerd in: (2013)

The RH5-CyRPA-Ripr complex as a malaria vaccine target
door: Ragotte, RJ, et al.
Gepubliceerd in: (2020)

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5
door: Thomas E Harrison, et al.
Gepubliceerd in: (2024-09-01)

Assessment of precision in growth inhibition assay (GIA) using human anti-PfRH5 antibodies
door: Miura, K, et al.
Gepubliceerd in: (2023)

Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria
door: Partey, F, et al.
Gepubliceerd in: (2018)

The erythrocyte binding antigens and PfRh proteins are targets of Plasmodium falciparum invasioninhibitory antibodies.
door: Persson, K, et al.
Gepubliceerd in: (2008)

Assessment of precision in growth inhibition assay (GIA) using human anti-PfRH5 antibodies
door: Kazutoyo Miura, et al.
Gepubliceerd in: (2023-05-01)

Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria.
door: Frederica D Partey, et al.
Gepubliceerd in: (2018-01-01)

The role of PfRh invasion ligands as targets of antibodies that protect against P-falciparum malaria.
door: Reiling, L, et al.
Gepubliceerd in: (2008)

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes
door: Lin Chen, et al.
Gepubliceerd in: (2014-10-01)

Correction: Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria.
door: Frederica D Partey, et al.
Gepubliceerd in: (2018-01-01)

The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody.
door: Douglas, A, et al.
Gepubliceerd in: (2011)

Functional characterization of plasmodium falciparum reticulocyte binding like protein homologue 1 (PfRH1)
door: Yap, Sally Shu Lin
Gepubliceerd in: (2015)

Insights into the design of an improved PfRH5 malaria immunogen using vaccine-induced monoclonal antibodies
door: Alanine, DGW
Gepubliceerd in: (2017)

The EBA and PfRh invasion ligand families of P-falciparum as targets of invasion-inhibitory and protective antibodies.
door: Beeson, J, et al.
Gepubliceerd in: (2008)

Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion
door: Tony Triglia, et al.
Gepubliceerd in: (2023-04-01)

Establishment of an Antiplasmodial Vaccine Based on PfRH5-Encoding RNA Replicons Stabilized by Cationic Liposomes
door: Wesley L. Fotoran, et al.
Gepubliceerd in: (2023-04-01)

Assessing the functional impact of PfRh5 genetic diversity on ex vivo erythrocyte invasion inhibition
door: Adam J. Moore, et al.
Gepubliceerd in: (2021-01-01)

Structure-guided insights into potential function of novel genetic variants in the malaria vaccine candidate PfRh5
door: Khadidiatou Mangou, et al.
Gepubliceerd in: (2022-11-01)

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex
door: Williams, BG, et al.
Gepubliceerd in: (2024)

An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum.
door: Lin Chen, et al.
Gepubliceerd in: (2011-09-01)

Correction: PfRH5: A Novel Reticulocyte-Binding Family Homolog of that Binds to the Erythrocyte, and an Investigation of Its Receptor.
door: Marilis Rodriguez, et al.
Gepubliceerd in: (2008-01-01)

Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against P. falciparum clinical isolates
door: Thiam, LG, et al.
Gepubliceerd in: (2024)

A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.
door: Douglas, A, et al.
Gepubliceerd in: (2015)

Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against P. falciparum clinical isolates
door: Laty G. Thiam, et al.
Gepubliceerd in: (2024-10-01)

A DNA Vaccine Encoding <i>Plasmodium falciparum</i> PfRH5 in Cationic Liposomes for Dermal Tattooing Immunization
door: Wesley Luzetti Fotoran, et al.
Gepubliceerd in: (2020-10-01)